The protective role of butyrate against obesity and obesity-related diseases

S Coppola, C Avagliano, A Calignano, R Berni Canani - Molecules, 2021 - mdpi.com
Worldwide obesity is a public health concern that has reached pandemic levels. Obesity is
the major predisposing factor to comorbidities, including type 2 diabetes, cardiovascular …

It is high time physicians thought of natural products for alleviating NAFLD. Is there sufficient evidence to use them?

G Tarantino, C Balsano, SJ Santini, G Brienza… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease all over
the world due to the obesity pandemic; currently, therapeutic options for NAFLD are scarce …

[HTML][HTML] Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis

KC Lee, PS Wu, HC Lin - Clinical and molecular hepatology, 2023 - ncbi.nlm.nih.gov
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …

Nonalcoholic fatty liver disease (NAFLD). Mitochondria as players and targets of therapies?

A Di Ciaula, S Passarella, H Shanmugam… - International Journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

[HTML][HTML] Differential effects of oleic and palmitic acids on lipid droplet-mitochondria interaction in the hepatic cell line HepG2

A Eynaudi, F Díaz-Castro, JC Bórquez… - Frontiers in …, 2021 - frontiersin.org
Fatty acid overload, either of the saturated palmitic acid (PA) or the unsaturated oleic acid
(OA), causes triglyceride accumulation into specialized organelles termed lipid droplets …

[HTML][HTML] Reactive oxygen species trigger NF-κB-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity

Y Pang, D Wu, Y Ma, Y Cao, Q Liu, M Tang, Y Pu… - Redox Biology, 2021 - Elsevier
Cadmium telluride (CdTe) quantum dots (QDs) can be employed as imaging and drug
delivery tools; however, the toxic effects and mechanisms of low-dose exposure are unclear …

Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy

Y Zheng, S Wang, J Wu, Y Wang - Journal of Translational Medicine, 2023 - Springer
Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread
metabolic disease globally, and its associated complications including insulin resistance …

Role of carnitine in non-alcoholic fatty liver disease and other related diseases: an update

N Li, H Zhao - Frontiers in medicine, 2021 - frontiersin.org
Carnitine is an amino acid-derived substance that coordinates a wide range of biological
processes. Such functions include transport of long-chain fatty acids from the cytoplasm to …

Coffee and lower risk of type 2 diabetes: arguments for a causal relationship

H Kolb, S Martin, K Kempf - Nutrients, 2021 - mdpi.com
Prospective epidemiological studies concur in an association between habitual coffee
consumption and a lower risk of type 2 diabetes. Several aspects of these studies support a …

Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …