Uraemic solutes as therapeutic targets in CKD-associated cardiovascular disease

JD Ravid, MH Kamel, VC Chitalia - Nature Reviews Nephrology, 2021 - nature.com
Chronic kidney disease (CKD) is characterized by the retention of a myriad of solutes termed
uraemic (or uremic) toxins, which inflict damage to several organs, including the …

Anthocyanins in chronic diseases: The power of purple

SK Panchal, OD John, ML Mathai, L Brown - Nutrients, 2022 - mdpi.com
Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as
secondary metabolites are important in plant survival. Understanding their health benefits in …

Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges

T Donia, A Khamis - Environmental Science and Pollution Research, 2021 - Springer
Cardiovascular diseases (CVDs) have diverse physiopathological mechanisms with
interconnected oxidative stress and inflammation as one of the common etiologies which …

Association between serum uric acid/HDL-cholesterol ratio and chronic kidney disease: a cross-sectional study based on a health check-up population

Y Cheng, H Zhang, H Zheng, H Yin, Y Wang, H Wang… - BMJ open, 2022 - bmjopen.bmj.com
Objective Evidence suggests that both serum uric acid (SUA) and high-density lipoprotein
cholesterol (HDL-C) are risk factors for chronic kidney disease (CKD). The SUA-to-HDL-C …

Mitochondrial dysfunction and oxidative stress: Role in chronic kidney disease

A Srivastava, B Tomar, D Sharma, SK Rath - Life Sciences, 2023 - Elsevier
Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

The interplay between uremic toxins and albumin, membrane transporters and drug interaction

RS Cunha, CAB Azevedo, CA Falconi, FF Ruiz… - Toxins, 2022 - mdpi.com
Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to
the progression of chronic kidney disease (CKD). These toxins are associated with kidney …

Does the composition of gut microbiota affect hypertension? Molecular mechanisms involved in increasing blood pressure

J Tokarek, E Budny, M Saar, J Kućmierz… - International Journal of …, 2023 - mdpi.com
Arterial hypertension is a chronic disease which is very prevalent contemporarily. The aim of
this review was to investigate the impact of gut microbiota on the development and potential …

Uremic toxins and frailty in patients with chronic kidney disease: a molecular insight

CT Chao, SH Lin - International journal of molecular sciences, 2021 - mdpi.com
The accumulation of uremic toxins (UTs) is a prototypical manifestation of uremic milieu that
follows renal function decline (chronic kidney disease, CKD). Frailty as a potential outcome …

Demand for Water-Soluble Vitamins in a Group of Patients with CKD versus Interventions and Supplementation—A Systematic Review

K Kędzierska-Kapuza, U Szczuko, H Stolińska… - Nutrients, 2023 - mdpi.com
Background: Increasingly, chronic kidney disease (CKD) is becoming an inevitable
consequence of obesity, metabolic syndrome, and diabetes. As the disease progresses, and …

Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal …

R Di Paola, A De, R Izhar, M Abate, S Zappavigna… - Genes, 2023 - mdpi.com
Chronic kidney disease (CKD) induces several systemic effects, including the accumulation
and production of uremic toxins responsible for the activation of various harmful processes …