Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Background Type I interferons (IFN-I) contribute to a broad range of rheumatic and
musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of …

Cellular intrinsic immunity, mediated by the expression of an array of interferon-stimulated
antiviral genes, is a vital part of host defense. We have previously used a bioinformatic …

Autoimmune rheumatic diseases pose many problems that have, in general, already been
solved in the field of cancer. The heterogeneity of each disease, the clinical similarities and …

Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …

Objectives To systematically review the literature for assay methods that aim to evaluate type
I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods Three …

Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase
family. Originally, it was identified as a membrane protein involved in maintaining plasma …

Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease
characterized by a broad spectrum of clinical and serological manifestations. This may …

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is
characterized by the production of autoantibodies specific for components of the cell nucleus …

Cells, the basic units of life, have striking differences at transcriptomic, proteomic and
epigenomic levels across tissues, organs, organ systems and organisms. The coordination …