Background Recent researches in the field of genetics have extended our knowledge
through the discovery of genetic factors associated with autoimmune diseases (AID) …

The pathogenesis of systemic lupus erythematosus (SLE) remains elusive to this day;
however, genetic, epigenetic, and environmental factors have been implicated to be …

Abstract Purpose of Review The purpose is to discuss the advances that genetics and
genomics have provided to better understand the molecular mechanisms behind SLE and …

Epigenetics is known to be an important mechanism in the pathogenesis of autoimmune
diseases. Epigenetic variations can act as integrators of environmental and genetic …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by
excessive activation of T and B lymphocytes and breakdown of immune tolerance to …

Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory
disease with genomic and non-genomic contributions to risk. We hypothesize that …

Patients with paediatric-onset systemic lupus erythematosus (SLE) often present with more
severe clinical courses than adult-onset patients. Although genome-wide DNA methylation …

Understanding the intricate relationships between gene expression levels and epigenetic
modifications in a genome is crucial to comprehending the pathogenic mechanisms of many …

The implementation of precision medicine requires the recruiting of patients in statistically
enough numbers, the possibility of obtaining enough materials, and the integration of data …

The heterogeneity of SLE is a major limitation when designing clinical trials and understand
ing the mechanisms of the disease. The analyses conducted before the new technologies …