[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

'Human-on-a-chip'developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals …

U Marx, H Walles, S Hoffmann… - Alternatives to …, 2012 - journals.sagepub.com
Various factors, including the phylogenetic distance between laboratory animals and
humans, the discrepancy between current in vitro systems and the human body, and the …

Soft-robotic ciliated epidermis for reconfigurable coordinated fluid manipulation

Z Ren, M Zhang, S Song, Z Liu, C Hong, T Wang… - Science …, 2022 - science.org
The fluid manipulation capabilities of current artificial cilia are severely handicapped by the
inability to reconfigure near-surface flow on various static or dynamically deforming three …

[HTML][HTML] Optimizing the culture environment and embryo manipulation to help maintain embryo developmental potential

JE Swain, D Carrell, A Cobo, M Meseguer, C Rubio… - Fertility and sterility, 2016 - Elsevier
With increased use of comprehensive chromosome screening (CCS), the question remains
as to why some practices do not experience the same high levels of clinical success after …

Recent progress in bovine in vitro‐derived embryo cryotolerance: Impact of in vitro culture systems, advances in cryopreservation and future considerations

LB Ferré, ME Kjelland, AM Taiyeb… - … in Domestic Animals, 2020 - Wiley Online Library
Contents Cryopreservation of in vitro‐derived bovine embryos is a crucial step for the
widespread reproduction and conservation of valuable high‐merit animals. Given the …

What is the reproductive potential of day 7 euploid embryos?

C Hernandez-Nieto, JA Lee, R Slifkin… - Human …, 2019 - academic.oup.com
STUDY QUESTION What is the rate of euploidy and the reproductive potential of embryos
biopsied after 6 days of development? SUMMARY ANSWER Embryos biopsied after 6 days …

Microfluidic sperm selection yields higher sperm quality compared to conventional method in ICSI program: A pilot study

F Anbari, MA Khalili, AM Sultan Ahamed… - Systems Biology in …, 2021 - Taylor & Francis
An appropriate preparation technique, should be capable of isolating highquality
spermatozoa for intracytoplasmic sperm injection (ICSI). The aim was to assess sperm …

Thinking big by thinking small: application of microfluidic technology to improve ART

JE Swain, D Lai, S Takayama, GD Smith - Lab on a Chip, 2013 - pubs.rsc.org
In Vitro Fertilization (IVF) laboratories often carry a penchant to resist change while in the
pursuit of maintaining consistency in laboratory conditions. However, implementation of new …

Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: translating lessons from murine models

KL Bruner-Tran, J Gnecco, T Ding, DR Glore… - Reproductive …, 2017 - Elsevier
Humans and other animals are exposed to a wide array of man-made toxicants, many of
which act as endocrine disruptors that exhibit differential effects across the lifespan. In …

In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct

S Wang, IV Larina - Cell reports, 2021 - cell.com
Developmental biologists have always relied on imaging to shed light on dynamic cellular
events. However, processes such as mammalian fertilization and embryogenesis are …