Short-and long-read metagenomics expand individualized structural variations in gut microbiomes
In-depth profiling of genetic variations in the gut microbiome is highly desired for
understanding its functionality and impacts on host health and disease. Here, by harnessing …
understanding its functionality and impacts on host health and disease. Here, by harnessing …
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
Sequence-specific control of gene expression on a genome-wide scale is an important
approach for understanding gene functions and for engineering genetic regulatory systems …
approach for understanding gene functions and for engineering genetic regulatory systems …
CRISPR/Cas9 for genome editing: progress, implications and challenges
F Zhang, Y Wen, X Guo - Human molecular genetics, 2014 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) protein 9 system provides a robust and multiplexable genome editing tool, enabling …
(Cas) protein 9 system provides a robust and multiplexable genome editing tool, enabling …
Multiplex genome engineering using CRISPR/Cas systems
Functional elucidation of causal genetic variants and elements requires precise genome
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short …
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short …
Cas9 as a versatile tool for engineering biology
RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic
repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the …
repeats (CRISPR)-Cas systems have dramatically transformed our ability to edit the …
Universal and naked-eye gene detection platform based on the clustered regularly interspaced short palindromic repeats/Cas12a/13a system
C Yuan, T Tian, J Sun, M Hu, X Wang, E Xiong… - Analytical …, 2020 - ACS Publications
Gold-nanoparticles-based colorimetric assay is an attractive detection format, but is limited
by the tedious and ineffective posthybridization manipulations for genomic analysis. Here …
by the tedious and ineffective posthybridization manipulations for genomic analysis. Here …
Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
G Gasiunas, R Barrangou… - Proceedings of the …, 2012 - National Acad Sciences
Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) systems provide adaptive immunity against viruses and plasmids in bacteria and …
(Cas) systems provide adaptive immunity against viruses and plasmids in bacteria and …
CRISPR-Cas for genome editing: Classification, mechanism, designing and applications
S Bhatia, SK Yadav - International Journal of Biological Macromolecules, 2023 - Elsevier
Clustered regularly interspersed short pallindromic repeats (CRISPR) and CRISPR
associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence …
associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence …
A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) systems provide bacteria and archaea with adaptive immunity against viruses and …
(Cas) systems provide bacteria and archaea with adaptive immunity against viruses and …
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …