SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B
Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its
intrinsic mechanisms have been largely unexplored in primates. In this study, we …
intrinsic mechanisms have been largely unexplored in primates. In this study, we …
CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence
Cullin-RING E3 ubiquitin ligases (CRLs), the largest family of multi-subunit E3 ubiquitin
ligases in eukaryotic cells, represent core cellular machinery for executing protein …
ligases in eukaryotic cells, represent core cellular machinery for executing protein …
Decoding aging-dependent regenerative decline across tissues at single-cell resolution
Y Cai, M Xiong, Z Xin, C Liu, J Ren, X Yang, J Lei, W Li… - Cell Stem Cell, 2023 - cell.com
Regeneration across tissues and organs exhibits significant variation throughout the body
and undergoes a progressive decline with age. To decode the relationships between aging …
and undergoes a progressive decline with age. To decode the relationships between aging …
[HTML][HTML] Histamine-related genes participate in the establishment of an immunosuppressive microenvironment and impact the immunotherapy response in …
X Zhang, P Zheng, B Meng, H Zhuang, B Lu… - Clinical and …, 2024 - Springer
Chronic inflammation is pivotal in the pathogenesis of hepatocellular carcinoma (HCC).
Histamine is a biologically active substance that amplifies the inflammatory and immune …
Histamine is a biologically active substance that amplifies the inflammatory and immune …