Caenorhabditis elegans as a complete model organism for biosafety assessments of nanoparticles

T Wu, H Xu, X Liang, M Tang - Chemosphere, 2019 - Elsevier
The number of biosafety evaluation studies of nanoparticles (NPs) using different biological
models is increasing with the rapid development of nanotechnology. Thus far, nematode …

Graphene nanoribbons: prospects of application in biomedicine and toxicity

OV Zakharova, EE Mastalygina, KS Golokhvast… - Nanomaterials, 2021 - mdpi.com
Graphene nanoribbons are a type of graphene characterized by remarkable electrical and
mechanical properties. This review considers the prospects for the application of graphene …

Exposure to multi-walled carbon nanotubes causes suppression in octopamine signal associated with transgenerational toxicity induction in C. elegans

Y Zhao, X Hua, Q Rui, D Wang - Chemosphere, 2023 - Elsevier
Multi-walled carbon nanotube (MWCNT), a kind of carbon-based nanomaterials, has been
extensively utilized in a variety of fields. In Caenorhabditis elegans, MWCNT exposure can …

Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematode Caenorhabditis elegans

S Dong, M Qu, Q Rui, D Wang - Ecotoxicology and environmental safety, 2018 - Elsevier
The possible adverse effects of nanoplastics have received the great attention recently;
however, their effects at environmentally relevant concentration on organisms are still …

UBIAD1 alleviates ferroptotic neuronal death by enhancing antioxidative capacity by cooperatively restoring impaired mitochondria and Golgi apparatus upon cerebral …

Y Huang, J Liu, J He, Z Hu, F Tan, X Zhu, F Yuan… - Cell & Bioscience, 2022 - Springer
Background Neuronal death due to over-oxidative stress responses defines the pathology of
cerebral ischemic/reperfusion (I/R) insult. Ferroptosis is a form of oxidative cell death that is …

Identification of signaling cascade in the insulin signaling pathway in response to nanopolystyrene particles

H Shao, Z Han, N Krasteva, D Wang - Nanotoxicology, 2019 - Taylor & Francis
The molecular response of animals to nanoplastic particles is still largely unclear. In this
study, we employed a modified prolonged exposure system to investigate the molecular …

Transgenerational toxicity of nanopolystyrene particles in the range of μg L− 1 in the nematode Caenorhabditis elegans

L Zhao, M Qu, G Wong, D Wang - Environmental Science: Nano, 2017 - pubs.rsc.org
The potential toxicity of nanoplastics to environmental organisms has gradually received
great attention recently. We employed the in vivo assay system of Caenorhabditis elegans to …

[HTML][HTML] Polystyrene nanoparticles strengthen high glucose toxicity associated with alteration in insulin signaling pathway in C. elegans

Z Zhuang, T Liu, Z Liu, D Wang - Ecotoxicology and Environmental Safety, 2024 - Elsevier
Using Caenorhabditis elegans as animal model, we investigated the effect of exposure to
polystyrene nanoparticles (PS-NPs) in the range of μg/L on high glucose toxicity induction …

Long-term exposure to polystyrene nanoparticles causes transgenerational toxicity by affecting the function and expression of MEV-1 and DAF-2 signals in …

L Zhang, S Wang, Y Zhao, B Nurdebek, Y Bu, D Wang - NanoImpact, 2022 - Elsevier
In this study, we determined the roles of oxidative stress and related signals in mediating
transgenerational toxicity of 30 nm polystyrene nanoparticles (PS-NPs) in Caenorhabditis …

Molecular basis for oxidative stress induced by simulated microgravity in nematode Caenorhabditis elegans

L Zhao, Q Rui, D Wang - Science of the Total Environment, 2017 - Elsevier
Caenorhabditis elegans is an important in vivo assay system for toxicological studies.
Herein, we investigated the role of oxidative stress and the underlying molecular mechanism …