Deletion of Spinophilin Promotes White Adipocyte Browning

W Gou, H Wei, L Swaby, E Green, H Wang - Pharmaceuticals, 2023 - mdpi.com
Browning of white adipose tissue (WAT) is suggested as a promising therapeutic approach
to induce energy expenditure and counteract obesity and its associated complications …

[HTML][HTML] Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming

CW Morris, DS Watkins, NR Shah, T Pennington… - Biological …, 2023 - Elsevier
Background Grooming dysfunction is a hallmark of the obsessive-compulsive spectrum
disorder trichotillomania. Numerous preclinical studies have utilized SAPAP3-deficient mice …

Mechanisms of spinophilin-dependent pancreas dysregulation in obesity

KC Stickel, NR Shah, ET Claeboe… - American Journal …, 2024 - journals.physiology.org
Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts
as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased …

[HTML][HTML] Mechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity

KC Stickel, AL Mosley, EH Doud, TL Belecky-Adams… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Objective: Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting
protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino−/−) mice …

[图书][B] Spinophilin Cell Type-Specifically Mediates Metabotropic Glutamate Receptor 5-Dependent Excessive Grooming

CW Morris - 2022 - search.proquest.com
Compulsive and repetitive behaviors in obsessive-compulsive spectrum disorders (OCSDs)
are associated with perturbations in the sensorimotor striatum. Repetitive behaviors are …

Spinophilin Signaling: Impacts on Body Weight, Obesity, and Beta-Cell Function

KC Stickel - 2023 - scholarworks.iupui.edu
Obesity is a worldwide epidemic that is partially linked to changing lifestyles within the
modern world, including increased access to calorically dense foods and decreased energy …