The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed
in the growth cones of nerve cells where they are involved in signal transmission and …

Pharmacologic targeting of chromatin-associated protein complexes has shown significant
responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance …

Background Pancreatic cancer is a heterogenous disease with a poor prognosis. This study
aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a …

Rationale: Brain metastasis in patients with lung cancer is life-threatening. However, the
molecular mechanism for this catastrophic disease remains elusive, and few druggable …

Lipids are present within the cell nucleus, where they engage with factors involved in gene
regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome …

Breast cancer is the most prevalent tumor in women worldwide and about 70% patients are
estrogen receptor positive. In these cancer patients, resistance to the anticancer estrogen …

The MYC protein is a transcription factor with oncogenic potential controlling fundamental
cellular processes such as cell proliferation, metabolism, differentiation, and apoptosis. The …

Intrinsically disordered proteins (IDPs) are characterized by the lack of a fixed tertiary
structure and are involved in the regulation of key biological processes via binding to …

The chemoresistance of temozolomide-based therapy is a serious limitation for lasting
effective treatment of gliomas, while the underlying mechanisms remain unclear. In this …

Aims In-stent restenosis and late stent thrombosis are complications associated with the use
of metallic and drug-coated stents. Strategies that inhibit vascular smooth muscle cell (SMC) …