Mammalian DNA methyltransferases methylate cytosine residues within CG dinucleotides.
By statistical analysis of published data of the Human Epigenome Project we have …

Heterochromatin remains condensed throughout the cell cycle, is generally transcriptionally
inert and is built and maintained by groups of factors with each group member sharing a …

The view that autosomal gene expression is controlled exclusively by protein trans-acting
factors has been challenged recently by the identification of RNA molecules that regulate …

Methylation of DNA at 5-position of cytosine, catalyzed by DNA methyltransferases, is the
predominant epigenetic modification in mammals. Aberrations in methylation play a causal …

Mutant mice simulating human CNS disorders are used as models for therapeutic drug
development. Drug evaluation requires a coherent correlation between behavioral …

Delorazepam, a derivative of diazepam, is a psychotropic drug belonging to the
benzodiazepine class. Used as a nervous-system inhibitor, it treats anxiety, insomnia, and …

How T cells regulate interleukin 4 (IL-4) expression is not completely understood. We show
here that single-positive thymocytes express IL-4, but attenuate GATA-3 expression, recruit …

MeCP2 is a DNA binding protein that represses transcription of methylated genes in vitro,
but the endogenous function of MeCP2 in vivo is unclear. Here, we demonstrate that in …

Previous studies documented significant behavioral changes in the offspring of cocaine-
exposed mothers. We now explore the hypothesis that maternal cocaine exposure could …

In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …