[HTML][HTML] Bactericidal activity of silver nanoparticles: A mechanistic review
Metallic nanoparticles such as silver nanoparticles (AgNPs) have gained lots of attention
due to the continuous upsurge in microbial infections and diseases, and also inefficient …
due to the continuous upsurge in microbial infections and diseases, and also inefficient …
Synthetic biology: applications come of age
AS Khalil, JJ Collins - Nature Reviews Genetics, 2010 - nature.com
Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …
biomolecular components, networks and pathways, and to use these constructs to rewire …
Interdependence of cell growth and gene expression: origins and consequences
M Scott, CW Gunderson, EM Mateescu, Z Zhang… - Science, 2010 - science.org
In bacteria, the rate of cell proliferation and the level of gene expression are intimately
intertwined. Elucidating these relations is important both for understanding the physiological …
intertwined. Elucidating these relations is important both for understanding the physiological …
Emergence of robust growth laws from optimal regulation of ribosome synthesis
M Scott, S Klumpp, EM Mateescu… - Molecular systems biology, 2014 - embopress.org
Bacteria must constantly adapt their growth to changes in nutrient availability; yet despite
large‐scale changes in protein expression associated with sensing, adaptation, and …
large‐scale changes in protein expression associated with sensing, adaptation, and …
Contextualizing context for synthetic biology–identifying causes of failure of synthetic biological systems
S Cardinale, AP Arkin - Biotechnology journal, 2012 - Wiley Online Library
Despite the efforts that bioengineers have exerted in designing and constructing biological
processes that function according to a predetermined set of rules, their operation remains …
processes that function according to a predetermined set of rules, their operation remains …
[HTML][HTML] Growth rate-dependent global effects on gene expression in bacteria
Bacterial gene expression depends not only on specific regulatory mechanisms, but also on
bacterial growth, because important global parameters such as the abundance of RNA …
bacterial growth, because important global parameters such as the abundance of RNA …
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Phenotypic cell-to-cell variability within clonal populations may be a manifestation of 'gene
expression noise',,,,,, or it may reflect stable phenotypic variants. Such 'non-genetic cell …
expression noise',,,,,, or it may reflect stable phenotypic variants. Such 'non-genetic cell …
Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology
Modular and orthogonal genetic logic gates are essential for building robust biologically
based digital devices to customize cell signalling in synthetic biology. Here we constructed …
based digital devices to customize cell signalling in synthetic biology. Here we constructed …
Single-RNA counting reveals alternative modes of gene expression in yeast
Proper execution of transcriptional programs is a key requirement of gene expression
regulation, demanding accurate control of timing and amplitude. How precisely the …
regulation, demanding accurate control of timing and amplitude. How precisely the …
Synthetic gene networks that count
Synthetic gene networks can be constructed to emulate digital circuits and devices, giving
one the ability to program and design cells with some of the principles of modern computing …
one the ability to program and design cells with some of the principles of modern computing …