Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Social cognition is a complex process that requires the integration of a wide variety of
behaviors, including salience, reward-seeking, motivation, knowledge of self and others …

Piperine (PIP) is a phytopharmaceutical with reported neuroprotective potential in
Alzheimer's disease (AD). Oral PIP delivery suffers from its hydrophobicity and pre-systemic …

Changes in the response to release of a single synaptic vesicle have generally been
attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now …

Alzheimer's disease (AD) is clinically characterized by progressive memory loss, behavioral
and learning dysfunction and cognitive deficits, such as alterations in social interactions. The …

The gut microbiota influence neurodevelopment, modulate behavior, and contribute to
neurodegenerative disorders. Several studies have consistently reported a greater …

This article is part of a Special Issue (“Estradiol and cognition”). Estrogens have repeatedly
been shown to influence a wide array of social behaviors, which in rodents are …

Beyond its importance in sustaining or modulating different aspects of the activity of the
central nervous system (CNS), the cholinergic system plays important roles during …

Acetylcholine, the first chemical to be identified as a neurotransmitter, is packed in synaptic
vesicles by the activity of VAChT (vesicular acetylcholine transporter). A decrease in VAChT …

Neurotransmitters, such as γ-aminobutyric acid, glutamate, acetyl choline, glycine and the
monoamines, facilitate the crosstalk within the central nervous system. The designated …