The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

TRAIL (tumor-necrosis factor related apoptosis-inducing ligand, CD253) and its death
receptors TRAIL-R1 and TRAIL-R2 selectively trigger the apoptotic cell death in tumor cells …

The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF superfamily that can initiate the apoptosis pathway by binding to its associated death …

Inhibitors of tumour necrosis factor (TNF) are among the most successful protein-based
drugs (biologics) and have proven to be clinically efficacious at reducing inflammation …

Apoptosis is a cell death program that is well-orchestrated for normal tissue homeostasis
and for removal of damaged, old or infected cells. It is regulated by intrinsic and extrinsic …

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies …