A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications

HI Shahin, L Chablani - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug
delivery. However, designing DPIs with adequate physicochemical properties is …

[HTML][HTML] In vitro dissolution and permeability testing of inhalation products: Challenges and advances

A Nokhodchi, S Chavan, T Ghafourian - Pharmaceutics, 2023 - mdpi.com
In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

Elucidation of the effect of added fines on the performance of dry powder inhalation formulations

M Stankovic-Brandl, S Radivojev, P Sailer… - International Journal of …, 2022 - Elsevier
Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic
fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is …

[HTML][HTML] Particulate bioaerogels for respiratory drug delivery

HY Li, C Makatsoris, B Forbes - Journal of Controlled Release, 2024 - Elsevier
The bioaerogel microparticles have been recently developed for respiratory drug delivery
and attract fast increasing interests. These highly porous microparticles have ultralow …

[HTML][HTML] The importance of dissolution for orally inhaled drug products: pharmaceutical, regulatory, and clinical considerations

K Somby, M Hingle, I Tomic… - Expert opinion on drug …, 2023 - Taylor & Francis
Almost all current orally inhaled drug products (OIDPs) are for the treatment of respiratory
diseases, and many have been designed using molecular or formulation strategies to retain …

Novel instrument to measure water uptake, dissolution and hygroscopic growth of an individual levitated aerosol particle in an environment identical to the lung …

A Haddrell, D Lewis, T Church… - Aerosol Science and …, 2024 - Taylor & Francis
Dry powder inhalers (DPIs) are commonly used devices for delivering inhalable
pharmaceuticals. The overall efficacy of any inhalable pharmaceutical is a function of total …

Improving Inhalation Performance with Particle Agglomeration via Combining Mechanical Dry Coating and Ultrasonic Vibration

Q Zhang, Z Wang, K Shi, H Zhou, X Wei, P Hall - Pharmaceutics, 2023 - mdpi.com
Agglomerate formulations for dry powder inhalation (DPI) formed with fine particles are
versatile means for the highly efficient delivery of budesonide. However, uncontrolled …

[HTML][HTML] An Enhanced Dissolving Cyclosporin-A Inhalable Powder Efficiently Reduces SARS-CoV-2 Infection In Vitro

D D'Angelo, E Quarta, S Glieca, G Varacca, L Flammini… - Pharmaceutics, 2023 - mdpi.com
This work illustrates the development of a dry inhalation powder of cyclosporine-A for the
prevention of rejection after lung transplantation and for the treatment of COVID-19. The …

In Vitro Assessment of Drug Release, Dissolution, and Absorption in the Lung

RS Bhattarai, V Kumar, K Nagapudi… - Organ Specific Drug …, 2022 - taylorfrancis.com
The lung is an attractive site for drug delivery for both local and systemic effects due to its
large surface area and rapid drug absorption by lung cells. Drug delivery to the lungs can be …

[HTML][HTML] Characterisation of an in vitro dissolution method for assessment of novel pulmonary drug delivery systems: With a focus on controlled release systems

I van der Zwaan - 2023 - diva-portal.org
Pulmonary drug delivery has been used for decades to treat local diseases like asthma.
When using the pulmonary route to deliver drugs, several important lung features are being …