G protein-coupled receptors are the target of more than 30% of all FDA-approved drug
therapies. Though the purinergic P2 receptors have been an attractive target for therapeutic …

Pulmonary arterial hypertension (PAH) is a life‐threatening disease characterized by
increased pulmonary arterial pressure and pulmonary vascular resistance, which result in …

Pulmonary arterial (PA) smooth muscle cells (PASMC) generate vascular tone in response
to agonists coupled to Gq-protein receptor signaling. Such agonists stimulate oscillating …

Spermatogenesis, the complex process of male germ cell proliferation, differentiation, and
maturation, is the basis of male fertility. In the seminiferous tubules of the testes …

The activation of purinergic receptors by nucleotides and/or nucleosides plays an important
role in the control of vascular function, including modulation of vascular smooth muscle …

Background: Boron is considered a trace element that induces various effects in systems of
the human body. However, each boron-containing compound exerts different effects …

Pulmonary vascular tone is modulated by nucleotides, but which P2 receptors mediate these
actions is largely unclear. The aim of this study, therefore, was to use subtype-selective …

Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and
physiologically relevant ex vivo model for studying the intricacies of lung diseases, including …

Numerous studies suggest the involvement of adenosine-5′-triphosphate (ATP) and similar
nucleotides in the pathophysiology of asthma. Androgens, such as testosterone (TES), are …

Extracellular nucleotides and nucleosides are crucial signalling molecules, eliciting diverse
biological responses in almost all organs and tissues. These molecules exert their effects by …