[HTML][HTML] Microneedle-enabled therapeutics delivery and biosensing in clinical trials

J Zhang, H Li, L Albakr, Y Zhang, A Lu, W Chen… - Journal of Controlled …, 2023 - Elsevier
Microneedles (MNs) are micron-sized protrusions attached to a range of devices that are
used in therapeutic delivery and diagnosis. Because MNs can be self-applied, are painless …

Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?

Z Qi, Z Yan, G Tan, T Jia, Y Geng, H Shao, SC Kundu… - Pharmaceutics, 2023 - mdpi.com
Microneedles are a patient-friendly technique for delivering drugs to the site of action in
place of traditional oral and injectable administration. Silk fibroin represents an interesting …

Photoresponsive polymeric microneedles: An innovative way to monitor and treat diseases

P Singh, B Youden, A Carrier, K Oakes… - Journal of Controlled …, 2023 - Elsevier
Microneedles (MN) technology is an emerging technology for the transdermal delivery of
therapeutics. When combined with photoresponsive (PR) materials, MNs can deliver …

Microneedle-assisted percutaneous delivery of methotrexate-loaded nanoparticles enabling sustained anti-inflammatory effects in psoriasis therapy

H Du, J Yang, M Li, Y Xia, Y Li, J Zhu… - Journal of Materials …, 2024 - pubs.rsc.org
Methotrexate (MTX) is one of the first-line drugs used for the treatment of moderate to severe
psoriasis. However, low bioavailability and systemic side effects of traditional oral and …

[HTML][HTML] Accelerated cascade melanoma therapy using enzyme-nanozyme-integrated dissolvable polymeric microneedles

P Singh, Y Chen, B Youden, D Oakley, A Carrier… - International Journal of …, 2024 - Elsevier
Dissolvable polymeric microneedles (DPMNs) have emerged as a powerful technology for
the localized treatment of diseases, such as melanoma. Herein, we fabricated a DPMN …

A landscape of recent advances in lipid nanoparticles and their translational potential for the treatment of solid tumors

RA Paun, S Jurchuk, M Tabrizian - … & Translational Medicine, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are biocompatible drug delivery systems that have found
numerous applications in medicine. Their versatile nature enables the encapsulation and …

Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders

S Priya, Y Tomar, VM Desai… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction For decades, finding effective long-term or disease-modifying treatments for skin
disorders has been a major focus of scientists. The conventional drug delivery systems …

Microneedles along with conventional therapies: An in-depth observational review in alopecia areata treatment

P Arora, R Shukla - Journal of Drug Delivery Science and Technology, 2024 - Elsevier
Alopecia areata (AA) is an emanating autoimmune disorder marked by short-term, non-
scarring loss of hair in distinct patches or of the entire scalp. The transdermal drug delivery …

Silk Fibroin Microneedles Loaded with Lipopolysaccharide-Pretreated Bone Marrow Mesenchymal Stem Cell-Derived Exosomes for Oral Ulcer Treatment

W Ge, Y Gao, Y Zeng, Y Yu, X Xie… - ACS Applied Materials & …, 2024 - ACS Publications
Oral ulcers, superficial lesions on the surface of the oral mucosa, have a high incidence rate,
and their main symptoms include local pain and erosion. Lipopolysaccharide (LPS) …

Overcoming challenges in dermal and transdermal delivery of herbal therapeutics with polymeric microneedles

A VM, S Suresh, A Kumar, PK, R NM… - Journal of …, 2024 - Taylor & Francis
Natural products are generally preferred medications owing to their low toxicity and irritancy
potential. However, a good number of herbal therapeutics (HT) exhibit solubility …