An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …
Anticoagulants for people hospitalised with COVID‐19
RLG Flumignan, VT Civile… - Cochrane Database …, 2022 - cochranelibrary.com
Background The primary manifestation of coronavirus disease 2019 (COVID‐19) is
respiratory insufficiency that can also be related to diffuse pulmonary microthrombosis and …
respiratory insufficiency that can also be related to diffuse pulmonary microthrombosis and …
Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: a systematic review and meta …
L Ortega-Paz, M Galli, D Capodanno… - European Heart …, 2022 - academic.oup.com
Background The clinical impact of different prophylactic anticoagulation regimens among
hospitalized patients with coronavirus disease 2019 (COVID-19) remains unclear. We …
hospitalized patients with coronavirus disease 2019 (COVID-19) remains unclear. We …
[HTML][HTML] Editor's Choice–Update of the European Society for Vascular Surgery (ESVS) 2020 clinical practice guidelines on the management of acute limb ischaemia in …
V Jongkind, JJ Earnshaw, FB Gonçalves… - European Journal of …, 2022 - Elsevier
Objective To perform a scoping review of how patients with COVID-19 are affected by acute
limb ischaemia (ALI) and evaluate the recommendations of the 2020 ESVS ALI Guidelines …
limb ischaemia (ALI) and evaluate the recommendations of the 2020 ESVS ALI Guidelines …
Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as a therapeutic target in COVID-19
LJ Weiss, M Drayss, G Manukjan, M Zeitlhöfler… - Blood …, 2023 - ashpublications.org
Thromboembolic events are frequent and life-threating complications of COVID-19 but are
also observed in patients with sepsis. Disseminated thrombosis can occur despite …
also observed in patients with sepsis. Disseminated thrombosis can occur despite …
Pharmacology of Heparin and Related Drugs: An Update
J Hogwood, B Mulloy, R Lever, E Gray… - Pharmacological Reviews, 2023 - ASPET
Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …
[HTML][HTML] High versus standard intensity of thromboprophylaxis in hospitalized patients with COVID-19: a systematic review and meta-analysis
Thromboprophylaxis in hospitalized patients with COVID-19 has been associated with a
survival benefit and is strongly recommended. However, the optimal dose of …
survival benefit and is strongly recommended. However, the optimal dose of …
[HTML][HTML] The role of heparin in COVID-19: An update after two years of pandemics
M Mangiafico, A Caff, L Costanzo - Journal of Clinical Medicine, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous
thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial …
thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial …
[HTML][HTML] Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding
Two years since the outbreak of the novel coronavirus SARS-CoV-2 (severe acute
respiratory syndrome coronavirus 2) pandemic, there remain few clinically effective drugs to …
respiratory syndrome coronavirus 2) pandemic, there remain few clinically effective drugs to …
[HTML][HTML] The benefits of heparin use in COVID-19: pleiotropic antiviral activity beyond anticoagulant and anti-inflammatory properties
Coronavirus disease 2019 (COVID-19), a life-threatening infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing the worst …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing the worst …