Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Obstructive sleep apnea (OSA) is a serious, potentially life-threatening condition.
Epidemiologic studies show that sleep apnea increases cardiovascular diseases risk factors …

Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Chronic pain has been associated with sleep disturbances in a bidirectional manner, with
pain disrupting sleep, and sleep deprivation or disturbance increasing pain. This …

OSA is a highly prevalent sleep disorder, and subjective excessive daytime sleepiness
(EDS) is the cardinal symptom for which many individuals seek medical advice. Positive …

Study Objectives: This review aimed to summarize current knowledge about disrupted
nighttime sleep (DNS) and sleep instability in narcolepsy, including self-reported and …

Summary Narcolepsy type 1 (NT1) is a lifelong disorder of sleep-wake dysregulation defined
by clinical symptoms, neurophysiological findings, and low hypocretin levels. Besides a role …

Abstract Study Objectives Evaluate efficacy and safety of lower-sodium oxybate (LXB), a
novel oxybate medication with 92% less sodium than sodium oxybate (SXB). Methods …

Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive
daytime sleepiness and cataplexy. The disease is considered to be the result of the selective …