The colonic crypt is home to several multipotent stem cells. These stem cells reside in a
niche at the base of the crypt, which controls their behavior and maintains the stem cell's …

Tumor stem cells are quiescent and, therefore, resistant to therapy, yet harbor the capacity to
replenish a tumor after therapy. Therefore, it is tempting to explain all therapeutic failures by …

The process of normal aging affects organ homeostasis as well as responses to acute and
chronic injury. In view of the rapid growth in the elderly population, it is increasingly …

Exosomes are lipid membrane bilayer-encapsulated vesicles secreted by cells into the
extracellular space. They carry abundant inclusions (such as nucleic acids, proteins, and …

A number of organs have the intrinsic ability to regenerate, a distinctive feature that varies
among organisms. Organ regeneration is a process not fully yet understood. However, when …

Renal cells are used in basic research, disease models, tissue engineering, drug screening,
and in vitro toxicology. In order to provide a reliable source of human renal cells, we …

In the present study, we tested the hypothesis that resident progenitor cells may contribute to
tumor vascularization and growth. CD133+ cells were isolated from 30 human renal …

Homeobox genes encode transcription factors that play essential roles in controlling cell
growth and differentiation during embryonic development. Many homeobox genes are …

The most commonly used therapeutic targets in nephrology are the reduction of injury, the
delay of progression, or renal replacement therapy. Many animal and human studies …

Renal failure has a high prevalence and is becoming a public health problem worldwide.
However, the renal replacement therapies such as dialysis are not yet satisfactory for its …