Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Priority effects transcend scales and disciplines in biology

JT Stroud, BM Delory, EM Barnes, JM Chase… - Trends in Ecology & …, 2024 - cell.com
Although primarily studied through the lens of community ecology, phenomena consistent
with priority effects appear to be widespread across many different scenarios spanning a …

The contribution of historical processes to contemporary extinction risk in placental mammals

AP Wilder, MA Supple, A Subramanian, A Mudide… - Science, 2023 - science.org
Species persistence can be influenced by the amount, type, and distribution of diversity
across the genome, suggesting a potential relationship between historical demography and …

Comparative transcriptomics reveals human-specific cortical features

NL Jorstad, JHT Song, D Exposito-Alonso, H Suresh… - Science, 2023 - science.org
The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Insights into mammalian TE diversity through the curation of 248 genome assemblies

AB Osmanski, NS Paulat, J Korstian, JR Grimshaw… - Science, 2023 - science.org
We examined transposable element (TE) content of 248 placental mammal genome
assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that …

Chiropterans are a hotspot for horizontal transfer of DNA transposons in Mammalia

NS Paulat, JM Storer… - Molecular biology …, 2023 - academic.oup.com
Horizontal transfer of transposable elements (TEs) is an important mechanism contributing
to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to …

Genomics expands the mammalverse

NS Upham, MJ Landis - Science, 2023 - science.org
Mammal genomics has progressed at an uneven pace—half sloth, half cheetah—owing to
various technical obstacles, including the complexity of eukaryotic genomes, difficulties …

[PDF][PDF] A timescale for placental mammal diversification based on Bayesian modeling of the fossil record

E Carlisle, CM Janis, D Pisani, PCJ Donoghue… - Current Biology, 2023 - cell.com
The timing of the placental mammal radiation has been the focus of debate over the efficacy
of competing methods for establishing evolutionary timescales. Molecular clock analyses …

Murine trophoblast organoids as a model for trophoblast development and CRISPR-Cas9 screening

Q Mao, Q Ye, Y Xu, J Jiang, Y Fan, L Zhuang, G Liu… - Developmental Cell, 2023 - cell.com
The placenta becomes one of the most diversified organs during placental mammal
radiation. The main in vitro model for studying mouse trophoblast development is the 2D …

Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements

ME Wirthlin, TA Schmid, JE Elie, X Zhang, A Kowalczyk… - Science, 2024 - science.org
Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To
identify brain genomic elements associated with mammalian vocal learning, we integrated …