Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
The role of the immune system in posttraumatic stress disorder
S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
JH Krystal, AP Kaye, S Jefferson… - Proceedings of the …, 2023 - National Acad Sciences
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
[HTML][HTML] Genetic insights into the neurobiology of anxiety
MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
Sex-based contributors to and consequences of post-traumatic stress disorder
Abstract Purpose of Review Women are twice as likely to develop post-traumatic stress
disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini …
disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini …
[HTML][HTML] Enhancing discovery of genetic variants for posttraumatic stress disorder through integration of quantitative phenotypes and trauma exposure information
Background Posttraumatic stress disorder (PTSD) is heritable and a potential consequence
of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD …
of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD …
Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
G Rompala, ST Nagamatsu… - Nature …, 2023 - nature.com
Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …