Tumor-associated macrophages (TAMs) constitute the main population of immune cells
present in the ovarian tumor microenvironment. These cells are characterized by high …

The omentum is a visceral adipose tissue with unique immune functions. Although it is
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …

Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterized by
immune structures called milky spots, but the cellular dynamics that direct this tropism are …

Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs)
play important roles in cancer progression. Here, we have characterized the ontogeny and …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

Metastasis is a complex multistep process that involves critical interactions between cancer
cells and a variety of stromal components in the tumor microenvironment, which profoundly …

Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …

Various types of tumors, particularly those originating from the ovary and gastrointestinal
tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The …

Protective immunity to Mycobacterium tuberculosis (Mtb)—the causative agent of
tuberculosis (TB)—is not fully understood but involves immune responses within the …

Background Ovarian cancer is the most lethal gynecologic cancer and the fifth leading
cause of cancer-related mortality in women worldwide. Despite various attempts to improve …