NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

N Xie, L Zhang, W Gao, C Huang, PE Huber… - Signal transduction and …, 2020 - nature.com
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Mitochondrial functions in infection and immunity

V Tiku, MW Tan, I Dikic - Trends in cell biology, 2020 - cell.com
Mitochondria have a central role in regulating a range of cellular activities and host
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …

Viral hijacking of cellular metabolism

SK Thaker, J Ch'ng, HR Christofk - BMC biology, 2019 - Springer
This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …

Innate metabolic responses against viral infections

CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

PJ Mullen, G Garcia Jr, A Purkayastha… - Nature …, 2021 - nature.com
Viruses hijack host cell metabolism to acquire the building blocks required for replication.
Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential …

[HTML][HTML] Viral activation of cellular metabolism

EL Sanchez, M Lagunoff - Virology, 2015 - Elsevier
To ensure optimal environments for their replication and spread, viruses have evolved to
alter many host cell pathways. In the last decade, metabolomic studies have shown that …

Predicting network activity from high throughput metabolomics

S Li, Y Park, S Duraisingham, FH Strobel… - PLoS computational …, 2013 - journals.plos.org
The functional interpretation of high throughput metabolomics by mass spectrometry is
hindered by the identification of metabolites, a tedious and challenging task. We present a …

How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication

W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2019 - frontiersin.org
Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D

N de Las Heras, VM Martín Giménez, L Ferder… - Antioxidants, 2020 - mdpi.com
Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has
put the health of the world population on alert. COVID-19 can provoke an acute inflammatory …

Dengue virus induces and requires glycolysis for optimal replication

KA Fontaine, EL Sanchez, R Camarda… - Journal of …, 2015 - Am Soc Microbiol
Viruses rely on host cellular metabolism to provide the energy and biosynthetic building
blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae …