NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Mitochondrial functions in infection and immunity
Mitochondria have a central role in regulating a range of cellular activities and host
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …
Viral hijacking of cellular metabolism
This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
Innate metabolic responses against viral infections
CS Palmer - Nature Metabolism, 2022 - nature.com
Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …
disease. At the systemic level, a significant feature of viral infection and inflammation that …
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
Viruses hijack host cell metabolism to acquire the building blocks required for replication.
Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential …
Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential …
[HTML][HTML] Viral activation of cellular metabolism
EL Sanchez, M Lagunoff - Virology, 2015 - Elsevier
To ensure optimal environments for their replication and spread, viruses have evolved to
alter many host cell pathways. In the last decade, metabolomic studies have shown that …
alter many host cell pathways. In the last decade, metabolomic studies have shown that …
Predicting network activity from high throughput metabolomics
The functional interpretation of high throughput metabolomics by mass spectrometry is
hindered by the identification of metabolites, a tedious and challenging task. We present a …
hindered by the identification of metabolites, a tedious and challenging task. We present a …
How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication
W Eisenreich, T Rudel, J Heesemann… - Frontiers in cellular and …, 2019 - frontiersin.org
Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …
host cells for efficient replication and proliferation during infection. In human infections, the …
Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D
N de Las Heras, VM Martín Giménez, L Ferder… - Antioxidants, 2020 - mdpi.com
Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has
put the health of the world population on alert. COVID-19 can provoke an acute inflammatory …
put the health of the world population on alert. COVID-19 can provoke an acute inflammatory …
Dengue virus induces and requires glycolysis for optimal replication
KA Fontaine, EL Sanchez, R Camarda… - Journal of …, 2015 - Am Soc Microbiol
Viruses rely on host cellular metabolism to provide the energy and biosynthetic building
blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae …
blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae …