[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …
RNA-binding proteins in cancer drug discovery
JB Bertoldo, S Müller, S Hüttelmaier - Drug discovery today, 2023 - Elsevier
Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
[HTML][HTML] A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation
A Fletcher, D Clift, E de Vries… - Nature …, 2023 - nature.com
Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions
as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor …
as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor …
Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …
several types of diseases, including cancer, making it a promising therapeutic target. We …
HuR modulation counteracts lipopolysaccharide response in murine macrophages
I Bonomo, G Assoni, V La Pietra… - Disease Models & …, 2023 - journals.biologists.com
Lipopolysaccharide (LPS) exposure to macrophages induces an inflammatory response,
which is regulated at the transcriptional and post-transcriptional levels. HuR (ELAVL1) is an …
which is regulated at the transcriptional and post-transcriptional levels. HuR (ELAVL1) is an …
[HTML][HTML] SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
S Lachiondo-Ortega, CM Rejano-Gordillo, J Simon… - Cell reports, 2024 - cell.com
The posttranslational modification of proteins critically influences many biological processes
and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R …
and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R …
miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R
Z Huang, Y Luo, C Chen, C Zhou, Z Su… - Canadian Journal of …, 2023 - Wiley Online Library
Human antigen R (HuR), also known as ELAVL1, is a widely expressed RNA‐binding
protein (RBP) that has a significant impact on the development and advancement of tumors …
protein (RBP) that has a significant impact on the development and advancement of tumors …
hucMSCs treatment ameliorated pulmonary fibrosis via downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 autophagic axis
R Li, H Zhang, J Zhang, Y Ji, W Liu, W Liu, M Wang… - Stem …, 2023 - academic.oup.com
This study was performed to determine the effect of human umbilical cord mesenchymal
stem cells (hucMSCs) treatment on pulmonary fibrosis and investigate the circFOXP1 …
stem cells (hucMSCs) treatment on pulmonary fibrosis and investigate the circFOXP1 …
LncRNA RMRP aggravates LPS-induced HK-2 cell injury and AKI mice kidney injury by upregulating COX2 protein via targeting ELAVL1
H Xia, X Shanshan, L Sumeng, X Fang, Z Tao… - International …, 2023 - Elsevier
Objectives There is emerging evidence that long non-coding RNA component of
mitochondrial RNA processing endoribonuclease (lncRNA RMRP) is involved in acute …
mitochondrial RNA processing endoribonuclease (lncRNA RMRP) is involved in acute …
[HTML][HTML] Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin …
Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested
potential activity against diverse types of cancer. However, low bioavailability and …
potential activity against diverse types of cancer. However, low bioavailability and …