Postpartum depression has deleterious effects on childbearing persons globally. Existing
treatments have been largely extrapolated from those for other forms of depression and …

Postpartum depression (PPD) is a debilitating psychiatric disorder characterized by a high
worldwide prevalence and serious long-term negative outcomes for both mothers and …

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …

Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of
synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series …

Therapeutic management of depression has currently important limitations, and its low
efficacy is reflected in high rates of non-response even after multiple trials of …

Background The endocannabinoid and neurosteroid systems regulate emotions and stress
responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the …

From a psychological perspective, the menstrual cycle has been a research topic for more
than 50 years. The most recent menstrual cycle research has been driven by an increased …

Objectives To systematically examine the effectiveness, tolerability, and safety of
brexanolone infusion in treating postpartum depression (PPD). Methods Randomized …

Background SAGE-217, a novel γ-aminobutyric acid A (GABA A) receptor positive allosteric
modulator, was evaluated in phase I, double-blind, placebo-controlled, single ascending …

Premenstrual dysphoric disorder is a female affective disorder that is defined by mood
symptoms. The condition is linked to unstable progesterone concentrations. Progestin …