Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

A Insua, A Monje, HL Wang… - Journal of biomedical …, 2017 - Wiley Online Library
Despite the growing number of publications in the field of implant dentistry, there are limited
studies to date investigating the biology and metabolism of bone healing around dental …

Marginal bone changes around platform‐switched conical connection implants placed 1 or 2 mm subcrestally: A multicenter crossover randomized controlled trial

C Stacchi, L Lamazza, A Rapani… - … Implant Dentistry and …, 2023 - Wiley Online Library
Introduction This study analyzes early marginal bone modifications occurring around
platform‐switched implants with conical connection placed 1 or 2 mm subcrestally. Methods …

[HTML][HTML] TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

K Horiguchi, K Sakamoto, D Koinuma, K Semba… - Oncogene, 2012 - nature.com
Epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair
and cancer progression in adult tissues. We have recently shown that transforming growth …

Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow

XL Lu, B Huo, V Chiang, XE Guo - Journal of Bone and Mineral …, 2012 - academic.oup.com
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation
by activating biochemical pathways and mediating the cellular activities of other bone cells …

Cellular communication in bone homeostasis and the related anti-osteoporotic drug development

Y Zhang, G Luo, X Yu - Current Medicinal Chemistry, 2020 - ingentaconnect.com
Background: Intercellular crosstalk among osteoblast, osteoclast, osteocyte and chondrocyte
is involved in the precise control of bone homeostasis. Disruption of this cellular and …

In silico experiments of bone remodeling explore metabolic diseases and their drug treatment

Y Kameo, Y Miya, M Hayashi, T Nakashima… - Science advances, 2020 - science.org
Bone structure and function are maintained by well-regulated bone metabolism and
remodeling. Although the underlying molecular and cellular mechanisms are now being …

Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress

T Adachi, Y Kameo, M Hojo - … Transactions of the …, 2010 - royalsocietypublishing.org
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system
are believed to play important roles in the mechanosensory system. Under dynamic loading …

Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting …

A Himeno-Ando, Y Izumi, A Yamaguchi… - … and biophysical research …, 2012 - Elsevier
The structural features of osteocytes and their cellular process network are thought to allow
for mechanotransduction from the bone tissue to these cells. This study applied three …

Ex vivo real-time observation of Ca2+ signaling in living bone in response to shear stress applied on the bone surface

Y Ishihara, Y Sugawara, H Kamioka, N Kawanabe… - Bone, 2013 - Elsevier
Bone cells respond to mechanical stimuli by producing a variety of biological signals, and
one of the earliest events is intracellular calcium ([Ca2+] i) mobilization. Our recently …

Spatiotemporal properties of intracellular calcium signaling in osteocytic and osteoblastic cell networks under fluid flow

D Jing, XL Lu, E Luo, P Sajda, PL Leong, XE Guo - Bone, 2013 - Elsevier
Mechanical stimuli can trigger intracellular calcium (Ca2+) responses in osteocytes and
osteoblasts. Successful construction of bone cell networks necessitates more elaborate and …