Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …

The cellular proteome performs highly varied functions to sustain life. Since most of these
functions require proteins to fold properly, they can be impaired by mutations that affect …

Neurons maintain axonal homeostasis via employing a unique organization of the
microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for …

Organismal physiology and survival are influenced by environmental conditions and linked
to protein quality control. Proteome integrity is achieved by maintaining an intricate balance …

Classical genetic analysis is invaluable for understanding the genetic interactions
underlying specific phenotypes, but requires laborious and subjective experiments to …

Retinal pigment epithelium (RPE) has essential functions, such as nourishing and
supporting the neural retina, and is of vital importance in the pathogenesis of age-related …

A hallmark of aging is loss of differentiated cell identity. Aged Drosophila midgut
differentiated enterocytes (ECs) lose their identity, impairing tissue homeostasis. To discover …

The decline in antioxidant defenses make it easily for human and animals to suffer from liver
damage and diseases induced by oxidative stress, causing enormous losses to human …

Iron regulatory proteins (IRPs) and iron regulatory element (IRE) systems are well known in
the progression of neurodegenerative disorders by regulating iron related proteins. IRPs are …

Ubiquitination is a post-translational modification (PTM) that induces protein degradation or
function alteration and plays crucial roles in aging and cancer. Previous ubiquitinomes of …