With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

Vanilloid receptor type 1 (VR1)(TRPV1) is a ligand-gated ion channel expressed on sensory
nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin …

Vasoactive neuropeptides including substance P and calcitonin gene-related peptide
(CGRP) are localised in sensory nerves which innervate blood vessels. These are the major …

Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion
neurones in culture Page 1 Capsazepine block of voltage-activated calcium channels in adult …

Capsaicin, the active ingredient in hot chilli peppers, has selective actions on unmyelinated
C-fibres and thinly myelinated A primary sensory neurones [37, 100](Table 1). Most …

The identification of compounds that can more effectively and safely treat both acute and
chronic pain states and, additionally, show a reduced tendency to elicit the side effects …

There has been recent evidence linking bradykinin (BK) receptors with inflammation. This
study has investigated the involvement of BK receptors in two models of persistent …

Capsaicin was postulated to exert its pharmacological actions by interacting at a specific
recognition site (receptor) expressed predominantly by primary afferent neurons. 2. The …

Inflammation, and the pain that accompanies it, is a natural response of the body. The
licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory, anti-edematous …