[HTML][HTML] Nuclear transport proteins: Structure, function, and disease relevance
Y Yang, L Guo, L Chen, B Gong, D Jia… - Signal Transduction and …, 2023 - nature.com
Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …
[HTML][HTML] Comprehensive structure and functional adaptations of the yeast nuclear pore complex
CW Akey, D Singh, C Ouch, I Echeverria, I Nudelman… - Cell, 2022 - cell.com
Nuclear pore complexes (NPCs) mediate the nucleocytoplasmic transport of
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
[HTML][HTML] Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …
[HTML][HTML] Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks
I Delint-Ramirez, L Konada, L Heady, R Rueda… - Molecular cell, 2022 - cell.com
Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks
(DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their …
(DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their …
[HTML][HTML] A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes
A Penzo, M Dubarry, C Brocas, M Zheng… - Nature …, 2023 - nature.com
Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …
[HTML][HTML] Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization
The nuclear pore complex (NPC) comprises more than 30 nucleoporins (NUPs) and is a
hallmark of eukaryotes. NUPs have been suggested to be important in regulating gene …
hallmark of eukaryotes. NUPs have been suggested to be important in regulating gene …
[HTML][HTML] Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials
Nucleus, as the machinery for genome transcription, play prominent roles to support the
fundamental cellular functions, the destruction of any of these specific parts would …
fundamental cellular functions, the destruction of any of these specific parts would …
SUMO in the regulation of DNA repair and transcription at nuclear pores
Two related post‐translational modifications, the covalent linkage of Ubiquitin and the Small
Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both …
Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both …
Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription
L Pan, X Song, J Song, C Shi, Z Wang… - Acta Pharmacologica …, 2023 - nature.com
Nuclear pore complex in the nuclear envelope plays an important role in controlling the
transportation of RNAs, proteins and other macromolecules between the nucleus and …
transportation of RNAs, proteins and other macromolecules between the nucleus and …