The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

Drug discovery and development are aimed at identifying new chemical molecular entities
(NCEs) with desirable pharmacokinetic profiles for high therapeutic efficacy. The plasma …

We developed a novel drug metabolism and pharmacokinetics (DMPK) analysis platform
named DruMAP. This platform consists of a database for DMPK parameters and programs …

Alzheimer's disease (AD) is a severe, growing, multifactorial disorder affecting millions of
people worldwide characterized by cognitive decline and neurodegeneration. The …

The heterogeneity of the Caco-2 cell line and differences in experimental protocols for
permeability assessment using this cell-based method have resulted in the high variability of …

Oral bioavailability (OBA)-related pharmacokinetic properties, such as aqueous solubility,
lipophilicity, and intestinal membrane permeability, play a significant role in drug discovery …

Protein tyrosine phosphatases (PTPs) are the group of enzymes that control both cellular
activity and the dephosphorylation of tyrosine (Tyr)-phosphorylated proteins. Dysregulation …

One solution to compensate for the shortage of publicly available data is to collect more
quality-controlled data from the private sector through public–private partnerships. However …

It is important to precisely predict the intestinal absorption ratio (Fa) at an early stage in the
discovery of orally available drugs because it directly influences drug efficacy …

Highlights•A framework for a public-private (PP) partnership was established in Japan.•This
PP partnership consortium was constructed by private and public sectors.•Pharmacokinetic …