Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
[HTML][HTML] Microfluidics meets 3D cancer cell migration
An early step of metastasis requires a complex and coordinated migration of invasive tumor
cells into the surrounding tumor microenvironment (TME), which contains extracellular …
cells into the surrounding tumor microenvironment (TME), which contains extracellular …
[HTML][HTML] Modelling liver cancer microenvironment using a novel 3D culture system
The tumor microenvironment and its contribution to tumorigenesis has been a focal highlight
in recent years. A two-way communication between the tumor and the surrounding …
in recent years. A two-way communication between the tumor and the surrounding …
[HTML][HTML] High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics
Z Zhu, S Li, D Wu, H Ren, C Ni, C Wang, N Xiang, Z Ni - Lab on a Chip, 2022 - pubs.rsc.org
Accurate and rapid diagnosis of malignant pleural and peritoneal effusions is critical due to
potential association with advanced disease stages or progression. Traditional …
potential association with advanced disease stages or progression. Traditional …
[HTML][HTML] Evaluation of cancer immunotherapy using mini-tumor chips
Rationale: Predicting tumor responses to adjuvant therapies can potentially help guide
treatment decisions and improve patient survival. Currently, tumor pathology, histology, and …
treatment decisions and improve patient survival. Currently, tumor pathology, histology, and …
[HTML][HTML] Recent advances of organ-on-a-chip in cancer modeling research
X Liu, Q Su, X Zhang, W Yang, J Ning, K Jia, J Xin, H Li… - Biosensors, 2022 - mdpi.com
Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …
remains one of the leading causes of death worldwide. Due to the unclear molecular …
[HTML][HTML] IDO1 inhibition reduces immune cell exclusion through inducing cell migration while PD-1 blockage increases IL-6 and-8 secretion from T cells in head and …
M Sieviläinen, J Saavalainen, S Adnan-Awad… - Frontiers in …, 2022 - frontiersin.org
Background Immune checkpoint inhibitors (ICIs), primarily anti-PD-1, are currently used to
treat patients with recurrent or metastatic head and neck squamous cell carcinoma …
treat patients with recurrent or metastatic head and neck squamous cell carcinoma …
[HTML][HTML] In vitro human cancer models for biomedical applications
Simple Summary Cancer is a leading cause of death worldwide. While numerous studies
have been conducted on cancer treatment, clinical treatment options for cancers are still …
have been conducted on cancer treatment, clinical treatment options for cancers are still …
Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis
C Sharkey, R White, M Finocchiaro… - Annual Review of …, 2024 - annualreviews.org
Recent advances in single-cell and multicellular microfluidics technology have provided
powerful tools for studying cancer biology and immunology. The ability to create controlled …
powerful tools for studying cancer biology and immunology. The ability to create controlled …
Coupling the COST reference plasma jet to a microfluidic device: a new diagnostic tool for plasma-liquid interactions
J Bissonnette-Dulude, S Coulombe… - Plasma Sources …, 2023 - iopscience.iop.org
Plasma-liquid interaction processes are central to plasma applications in medicine,
environment, and material processing. However, a standardized platform that allows the …
environment, and material processing. However, a standardized platform that allows the …