[HTML][HTML] The role of epigenetics in autoimmune/inflammatory disease
AEA Surace, CM Hedrich - Frontiers in immunology, 2019 - frontiersin.org
Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …
and caused by the innate immune system or autoimmune and driven by adaptive immune …
Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options
EMD Smith, H Lythgoe, A Midgley, MW Beresford… - Clinical …, 2019 - Elsevier
Juvenile-onset systemic lupus erythematosus (jSLE) accounts for up to 20% of all SLE
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …
A genetics-led approach defines the drug target landscape of 30 immune-related traits
H Fang, H De Wolf, B Knezevic, KL Burnham… - Nature …, 2019 - nature.com
Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of
efficacy on early target selection. Drug targets with genetic support are more likely to be …
efficacy on early target selection. Drug targets with genetic support are more likely to be …
Protecting the kidney in systemic lupus erythematosus: from diagnosis to therapy
NI Maria, A Davidson - Nature Reviews Rheumatology, 2020 - nature.com
Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus that can
lead to irreversible renal impairment. Although the prognosis of LN has improved …
lead to irreversible renal impairment. Although the prognosis of LN has improved …
Type I interferons in host defence and inflammatory diseases
MK Crow, L Ronnblom - Lupus Science & Medicine, 2019 - lupus.bmj.com
Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …
beneficial or detrimental to the individual depending on whether IFN pathway activation is …
The molecular structure and biological functions of RNA methylation, with special emphasis on the roles of RNA methylation in autoimmune diseases
W Zhou, X Wang, J Chang, C Cheng… - Critical Reviews in …, 2022 - Taylor & Francis
Autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus
(SLE), and systemic vasculitis are caused by the body's immune response to autoantigens …
(SLE), and systemic vasculitis are caused by the body's immune response to autoantigens …
Juvenile-onset systemic lupus erythematosus (jSLE)–Pathophysiological concepts and treatment options
CM Hedrich, EMD Smith, MW Beresford - Best practice & research Clinical …, 2017 - Elsevier
The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE)
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …
The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus
Q Luo, J Rao, L Zhang, B Fu, Y Guo… - Molecular Genetics & …, 2020 - Wiley Online Library
Background This study was aimed to explore the mRNA expression of m6A
“writers”(METTL3, MTEEL14, and WTAP),“erasers”(FTO and ALKBH5), and …
“writers”(METTL3, MTEEL14, and WTAP),“erasers”(FTO and ALKBH5), and …
[HTML][HTML] Systemic lupus erythematosus in primary care: an update and practical messages for the general practitioner
I Gergianaki, G Bertsias - Frontiers in medicine, 2018 - frontiersin.org
Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease that
manifests a wide range of organ involvement. Traditionally, the diagnosis and management …
manifests a wide range of organ involvement. Traditionally, the diagnosis and management …
The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus …
C Zhang, X Wang, Y Chen, Z Wu, C Zhang… - Clinical …, 2018 - portlandpress.com
Background: Systemic lupus erythematous (SLE) is an autoimmune disease characterized
by the production of autoantibodies directed against various autoantigens. But the …
by the production of autoantibodies directed against various autoantigens. But the …