Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …

Juvenile-onset systemic lupus erythematosus (jSLE) accounts for up to 20% of all SLE
patients. Key differences between juvenile-and adult-onset (aSLE) disease include higher …

Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of
efficacy on early target selection. Drug targets with genetic support are more likely to be …

Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus that can
lead to irreversible renal impairment. Although the prognosis of LN has improved …

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …

Autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus
(SLE), and systemic vasculitis are caused by the body's immune response to autoantigens …

The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE)
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …

Background This study was aimed to explore the mRNA expression of m6A
“writers”(METTL3, MTEEL14, and WTAP),“erasers”(FTO and ALKBH5), and …

Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease that
manifests a wide range of organ involvement. Traditionally, the diagnosis and management …

Background: Systemic lupus erythematous (SLE) is an autoimmune disease characterized
by the production of autoantibodies directed against various autoantigens. But the …