Neurodegenerative diseases and spinal cord injury affect approximately 50 million people
worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous …

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for
the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is
associated with functional brain alterations that underlie the expression of behaviour. Males …

Ischemic stroke, mostly caused by thromboembolic or thrombotic arterial occlusions, is a
primary leading cause of death worldwide with high morbidity and disability. Unfortunately …

Background Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase with multiple
roles in tumour growth, cell invasion and metastasis. We have previously established GSK-3 …

Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective
cancer immunotherapy for tumors that are immune inflamed or induced to become “hot”. It …

Alzheimer's disease (AD) is an emerging major health and socioeconomic burden
worldwide. It is characterized by neuronal loss, memory loss and cognitive impairment in the …

Inhibition of glycogen synthase kinase (GSK)-3 and the consequent activation of the Wnt/β-
catenin signaling pathway have been reported to increase bone volume. To develop a novel …

Abstract Both cholinesterases (AChE and BChE) and kinases, such as GSK-3α/β, are
associated with the pathology of Alzheimer's disease. Two scaffolds, targeting AChE …

Glycogen synthase kinase-3 is a multi-functional serine-threonine kinase and is involved in
diverse physiological processes, including metabolism, cell cycle, and gene expression by …