T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …

Abstract Type 1 diabetes (T1D) is usually caused by immune-mediated destruction of islet β
cells, and genetic and environmental factors are thought to trigger autoimmunity. Convincing …

Objective The association between enterovirus infection and type 1 diabetes (T1D) is
controversial, and this meta-analysis aimed to explore the correlation. Methods PubMed …

Aims Our study aimed to review the impact of COVID-19 pandemia in children and
adolescents with type 1 diabetes mellitus, to analyze the clinical characteristics of the …

Enteroviral infections have been associated with autoimmunity and type 1 diabetes (T1D),
but reliable methods to ascertain localization of single infected cells in the pancreas were …

Abstract Purpose of Review We provide an overview of the current knowledge regarding the
natural history of human type 1 diabetes (T1D) and the documented associations between …