ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

Recent evidence indicates a link between gut pathology and microbiome with hypertension
(HTN) in animal models. However, whether this association exists in humans is unknown …

Discovery of ACE2 (angiotensin-converting enzyme 2) revealed that the renin-angiotensin
system has 2 counterbalancing arms. ACE2 is a major player in the protective arm, highly …

Aim High blood pressure (BP) is associated with gut microbiota dysbiosis. The aim of this
study was to investigate whether changes in gut microbiota induced by exchanging the gut …

Background The human gut microbiota (GM) is involved in the pathogenesis of hypertension
(HTN), and could be affected by various factors, including sex and geography. However …

Nitric oxide (NO) importantly contributes to cardiovascular homeostasis by regulating blood
flow and maintaining endothelial integrity. Conversely, reduced NO bioavailability is a …

Arterial blood pressure (BP) is regulated by a complex network of peripheral and central
(brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the …

A large number of different microbial species populates intestine. Extensive research has
studied the entire microbial population and their genes (microbiome) by using …

Metformin is a common drug for the management of type 2 diabetes mellitus; however, it
causes various adverse gastrointestinal effects, especially after prolonged treatment. It is …