Metabolic engineering: methodologies and applications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
[HTML][HTML] Machine learning for metabolic engineering: A review
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …
engineering more predictable. In this review, we offer an introduction to this discipline in …
Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
The ModelSEED Biochemistry Database for the integration of metabolic annotations and the reconstruction, comparison and analysis of metabolic models for plants …
For over 10 years, ModelSEED has been a primary resource for the construction of draft
genome-scale metabolic models based on annotated microbial or plant genomes. Now …
genome-scale metabolic models based on annotated microbial or plant genomes. Now …
Development of a commercial scale process for production of 1, 4-butanediol from sugar
A Burgard, MJ Burk, R Osterhout, S Van Dien… - Current opinion in …, 2016 - Elsevier
Highlights•Genomatica has developed a commercial bioprocess for the production of 1, 4-
butanediol from dextrose.•A systems biology approach enabled rapid identification and …
butanediol from dextrose.•A systems biology approach enabled rapid identification and …
[HTML][HTML] A machine learning approach to predict metabolic pathway dynamics from time-series multiomics data
Z Costello, HG Martin - NPJ systems biology and applications, 2018 - nature.com
New synthetic biology capabilities hold the promise of dramatically improving our ability to
engineer biological systems. However, a fundamental hurdle in realizing this potential is our …
engineer biological systems. However, a fundamental hurdle in realizing this potential is our …
Systems biology of metabolism
J Nielsen - Annual review of biochemistry, 2017 - annualreviews.org
Metabolism is highly complex and involves thousands of different connected reactions; it is
therefore necessary to use mathematical models for holistic studies. The use of …
therefore necessary to use mathematical models for holistic studies. The use of …
From microbiome composition to functional engineering, one step at a time
Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …
[HTML][HTML] A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
A Khodayari, CD Maranas - Nature communications, 2016 - nature.com
Kinetic models of metabolism at a genome scale that faithfully recapitulate the effect of
multiple genetic interventions would be transformative in our ability to reliably design novel …
multiple genetic interventions would be transformative in our ability to reliably design novel …
[HTML][HTML] Kinetic models in industrial biotechnology–improving cell factory performance
An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …
cell factories that convert sugars into chemicals. These processes range from the production …