Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with
notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the …

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

Chlorpyrifos (CP) and its highly electrophilic intermediates are principal toxic metabolites.
The active form of CP ie chlorpyrifos oxon (CP-oxon) is responsible for both the insecticidal …

The purpose of this review is to examine uses of carboxylesterase activity in environmental
monitoring with a specific emphasis on pyrethroid insecticides. The chapter begins with an …

Nanomedicines generally consisting of carrier materials with small fractions of active
pharmaceutical ingredients (API) have long been used to improve the pharmacokinetics and …

Butyrylcholinesterase (BChE) is present in plasma and numerous cells and organs. Its
physiological function (s) is (are) still unclear. However, this enzyme is of pharmacological …

Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages
over parent drugs such as increased solubility, enhanced stability, improved bioavailability …

Triterpenoids are structurally diverse organic compounds that exist widely as natural
products. Triterpenoids and their derivatives possess a wide range of biological effects …

Hydrolytic metabolism of pyrethroid insecticides in humans is one of the major catabolic
pathways that clear these compounds from the body. Rodent models are often used to …