The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

Transmembrane activator and calcium‐modulating cyclophilin ligand interactor (TACI) is
one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and …

Senescent cells release a variety of cytokines, proteases, and growth factors collectively
known as the senescence-associated secretory phenotype (SASP). Sustained SASP …

Common variable immunodeficiency (CVID) is the most frequently diagnosed primary
antibody deficiency. About half of CVID patients develop chronic non-infectious …

Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface
expression and ligand-mediated survival of B cell subsets. This shedding is executed by …

Introduction: The B-cell activating factor (BAFF) axis comprises two ligands (BAFF and
APRIL) and three receptors (BCMA, TACI, BR3). BAFF is a vital B-cell survival factor and …

B cell activating factor (BAFF or BLyS), an important cytokine for B cell survival and humoral
immune responses, is targeted in the clinic for the treatment of systemic lupus …

The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is
targeted in the clinic for the treatment of systemic lupus erythematosus. BAFF contains a …

B cell activating factor of the TNF family (BAFF, also known as BLyS), a cytokine that
regulates homeostasis of peripheral B cells, is elevated in the circulation of patients with …

The TNF family member, transmembrane activator and calcium-modulator and cyclophilin
ligand interactor (TACI), is a key molecule for plasma cell maintenance and is required in …