Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite
profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are …

Senescence is the consequence of a signaling mechanism activated in stressed cells to
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a …

Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …

Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …

Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …