Macrophages stand in the first line of defense against a variety of pathogens but are also
involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages …

The goal of cancer immunotherapy is to clear tumor cells by activating antitumor immunity,
especially by mobilizing tumor-reactive CD8+ T cells. Pyroptosis, programmed lytic cell …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

Background Diabetic nephropathy (DN) is prevalent in patients with diabetes. N 6-
methyladenosine (m6A) methylation has been found to cause modification of nucleotide …

Pyroptosis is an inflammatory form of cell death executed by transmembrane pore-forming
proteins known as gasdermins and can be activated in an inflammasome-dependent or …

Inflammasomes are multimolecular complexes with potent inflammatory activity. As such,
their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …

Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is
exceptional from other types of cell death programs. Particularly, pyroptosis is characterized …

Redox changes and generation of reactive oxygen species (ROS) are part of normal cell
metabolism. While low ROS levels are implicated in cellular signaling pathways necessary …