[HTML][HTML] The role of glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome

K Bednarz, K Kowalczyk, M Cwynar, D Czapla… - International journal of …, 2022 - mdpi.com
Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary
syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a …

[HTML][HTML] Cardiovascular effects of glucagon-like peptide 1 (GLP-1) receptor agonists

FK Saraiva, AC Sposito - Cardiovascular Diabetology, 2014 - Springer
Patients with type 2 diabetes have a several-fold increased risk of developing
cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and …

[HTML][HTML] Symptomatic and disease-modifying therapy pipeline for Alzheimer's disease: Towards a personalized polypharmacology patient-centered approach

X Morató, V Pytel, S Jofresa, A Ruiz… - International Journal of …, 2022 - mdpi.com
Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …

[HTML][HTML] Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

Y Chen, J Du, YT Zhao, L Zhang, G Lv… - Cardiovascular …, 2015 - Springer
Background Recent evidence indicates that inhibition of histone deacetylase (HDAC)
protects the heart against myocardial injury and stimulates endogenous angiomyogenesis …

[HTML][HTML] Sensory nutrition and bitterness and astringency of polyphenols

N Osakabe, T Shimizu, Y Fujii, T Fushimi, V Calabrese - Biomolecules, 2024 - mdpi.com
Recent studies have demonstrated that the interaction of dietary constituents with taste and
olfactory receptors and nociceptors expressed in the oral cavity, nasal cavity and …

AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes

M Balteau, A Van Steenbergen… - American Journal …, 2014 - journals.physiology.org
Exposure of cardiomyocytes to high glucose concentrations (HG) stimulates reactive oxygen
species (ROS) production by NADPH oxidase (NOX2). NOX2 activation is triggered by …

GLP-1 receptor agonists and heart failure in diabetes

AJ Scheen - Diabetes & metabolism, 2017 - Elsevier
The prevalence of heart failure (HF) is increasing in patients with type 2 diabetes (T2D), and
glucose-lowering agents have distinctive effects on the risk of developing HF that requires …

Mechanisms involved in cardioprotection induced by physical exercise

C Penna, G Alloatti, A Crisafulli - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Regular exercise training can reduce myocardial damage caused by acute
ischemia/reperfusion (I/R). Exercise can reproduce the phenomenon of ischemic …

A prospective randomized controlled trial of the metabolic effects of sleeve gastrectomy with transit bipartition

FR Azevedo, S Santoro, ML Correa-Giannella… - Obesity surgery, 2018 - Springer
Purpose To compare the effects of the sleeve gastrectomy with transit bipartition (SG+ TB)
procedure with standard medical therapy (SMT) in mildly obese patients with type II diabetes …

[HTML][HTML] Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients

CJ Li, Q Yu, P Yu, TL Yu, QM Zhang, S Lu… - Cardiovascular …, 2014 - Springer
Background and aims Liraglutide treatment can improve glycemic control with a concomitant
weight loss, but the underlying mechanism on weight loss is not completely understood …