Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Background and Objective: Despite striking advances in multimodality management, gastric
cancer (GC) remains the third cause of cancer mortality globally and identifying novel …

Mammalian carboxylesterases (CESs) are essential members of serine esterase hydrolase
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …

The metabolism in eukaryotic cells is a highly ordered system involving various cellular
compartments, which fluctuates based on physiological rhythms. Organelles, as the smallest …

Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Hydrolytic reactions constitute an important pathway of drug metabolism and a significant
route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that …

Carboxylesterases (CEs) play great role in CEs-related diseases and drug metabolism.
Selectively monitoring its activity is important to explore its role in CEs-related diseases and …

Many drug oxidations and conjugations are mediated by a variety of cytochromes P450
(P450) and non-P450 enzymes in humans and non-human primates. These non-P450 …

Multidrug-resistant bacteria are increasingly isolated from the urinary tract of pets,
particularly those that suffer from concurrent conditions, have been hospitalised, or were …

Background T-2 toxin is recognized as one of the high-risk environmental factors for etiology
and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased …