Pathophysiology and treatment of cerebral edema in traumatic brain injury

RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Blood–spinal cord barrier in spinal cord injury: a review

LY Jin, J Li, KF Wang, WW Xia, ZQ Zhu… - Journal of …, 2021 - liebertpub.com
The blood–spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Curcumin's nanomedicine formulations for therapeutic application in neurological diseases

B Salehi, D Calina, AO Docea, N Koirala… - Journal of Clinical …, 2020 - mdpi.com
The brain is the body's control center, so when a disease affects it, the outcomes are
devastating. Alzheimer's and Parkinson's disease, and multiple sclerosis are brain diseases …

Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats

V Kant, A Gopal, NN Pathak, P Kumar… - International …, 2014 - Elsevier
Prolonged inflammation and increased oxidative stress impairs healing in diabetics and
application of curcumin, a well known antioxidant and anti-inflammatory agent, could be an …

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

H Zhu, C Bian, J Yuan, W Chu, X Xiang, F Chen… - Journal of …, 2014 - Springer
Background Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that
contributes to substantial neuronal damage and behavioral impairment, and Toll-like …

Curcumin in inflammatory diseases

A Shehzad, G Rehman, YS Lee - Biofactors, 2013 - Wiley Online Library
Curcumin (diferuloylmethane), a yellow coloring agent extracted from turmeric is also used
as a remedy for the treatment and prevention of inflammatory diseases. Acute and chronic …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …

[HTML][HTML] Reactive astrocytes as therapeutic targets for CNS disorders

ME Hamby, MV Sofroniew - Neurotherapeutics, 2010 - Elsevier
Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies.
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …

High mobility group box protein‐1 promotes cerebral edema after traumatic brain injury via activation of toll‐like receptor 4

MD Laird, JS Shields, S Sukumari‐Ramesh… - Glia, 2014 - Wiley Online Library
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Cerebral
edema, a life‐threatening medical complication, contributes to elevated intracranial pressure …