Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …

B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …

Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or
pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in …

Osteoarthritis—the most common form of age-related degenerative whole-joint disease—is
primarily characterized by cartilage destruction, as well as by synovial inflammation …

Ageing, infections and inflammation result in oxidative stress that can irreversibly damage
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by
upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription …