Arterial inflammation is a hallmark of atherosclerosis, and appropriate management of this
inflammation represents a major unmet therapeutic need for cardiovascular disease …

Natural killer (NK) cells develop from common progenitors but diverge into distinct subsets,
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …

Diets high in cholesterol alter intestinal immunity. Here, we examined how the cholesterol
metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice …

Cholesterol is a critical lipid for all mammalian cells, ensuring proper membrane integrity,
fluidity, and biochemical function. Accumulating evidence indicates that macrophages …

Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture
and regulate lymphocyte compartmentalization, homeostasis, and innate and adaptive …

The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main
protease, Spike protein, and RNA polymerase), compared with proteins of other human …

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …

Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps
of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians …

Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease
caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death …

Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently,
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …