The mechanisms controlling CD4+ T cell switching from an effector to an anti-inflammatory
(IL-10+) phenotype play an important role in the persistence of chronic inflammatory …

Effector T cells leave the lymph nodes armed with specialized functional attributes. Their
antigenic targets may be located anywhere in the body, posing the ultimate challenge: how …

Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture
and regulate lymphocyte compartmentalization, homeostasis, and innate and adaptive …

Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently,
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …

Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic
approaches for the treatment of cancer. However, the efficacy of CAR NK/T cell therapy is …

Abstract The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that
upregulate a suite of genes that together promote coordinated mobilization of excess …

Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood
and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB …

Abstract X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a
progressive neurodegenerative disorder associated with the accumulation of very long …

Background Genome-wide association studies of Alzheimer's disease (AD) have implicated
pathways related to lipid homeostasis and innate immunity in AD pathophysiology …

Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease
caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death …