Cancer progression generates a chronic inflammatory state that dramatically influences
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …

Oxysterols have long been known for their important role in cholesterol homeostasis, where
they are involved in both transcriptional and posttranscriptional mechanisms for controlling …

Background Therapies targeting estrogenic stimulation in estrogen receptor-positive (ER+)
breast cancer (BC) reduce mortality, but resistance remains a major clinical problem …

The goal of this study was to identify the intrinsic links that explain the effect of a Western diet
(WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either a …

Itaconate is a newly discovered mammalian metabolite bearing significant implications for
our understanding of cellular immunometabolism and antimicrobial defense. Here, we …

Interferons (IFNs) are potent pleiotropic cytokines that broadly alter cellular functions in
response to viral and other infections. These alterations include changes in protein …

Lipid droplets (LDs) are commonly found in various biological cells and are organelles
related to cell metabolism. LDs, the number and size of which are heterogeneous across cell …

Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …

Influx of eosinophils into the lungs is typically associated with type II responses during
allergy and fungal and parasitic infections. However, we previously reported that eosinophils …

Alveolar macrophages (AM) play a central role in initiation and resolution of lung
inflammation, but the integration of these opposing core functions is poorly understood. AM …