As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered
through interactions with phospholipids and transmembrane domains of proteins. However …

Cholesterol has typically been considered an exogenous, disease-related factor in
immunity; however, recent literature suggests that a paradigm shift is in order. Sterols are …

Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …

Rheumatic diseases can be divided in two groups, autoinflammatory and autoimmune
disorders. The clinical presentation of both types of diseases overlap, but the pathological …

Recent studies reported a broad but selective antiviral activity of 25-hydroxycholesterol
(25HC) against enveloped viruses, being apparently inactive against non-enveloped …

A novel innate immune strategy, involving specific cholesterol oxidation products as
effectors, has begun to reveal connections between cholesterol metabolism and immune …

Hematopoiesis is sustained throughout life by hematopoietic stem cells (HSCs) that are
capable of self-renewal and differentiation into hematopoietic progenitor cells (HPCs). There …

B‐cell responses are dynamic processes that depend on multiple types of interactions. Rare
antigen‐specific B cells must encounter antigen and specialized systems are needed …

The architecture of biological membranes is tightly coupled to the localization, organization,
and function of membrane proteins. The organelle-specific distribution of lipids allows for the …