Multiple roles of 25‐hydroxycholesterol in lipid metabolism, antivirus process, inflammatory response, and cell survival
Q Cao, Z Liu, Y Xiong, Z Zhong… - Oxidative Medicine and …, 2020 - Wiley Online Library
As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …
A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection
DB Heisler, KA Johnson, DH Ma, MB Ohlson, L Zhang… - Elife, 2023 - elifesciences.org
Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered
through interactions with phospholipids and transmembrane domains of proteins. However …
through interactions with phospholipids and transmembrane domains of proteins. However …
The intracellular cholesterol landscape: dynamic integrator of the immune response
MB Fessler - Trends in immunology, 2016 - cell.com
Cholesterol has typically been considered an exogenous, disease-related factor in
immunity; however, recent literature suggests that a paradigm shift is in order. Sterols are …
immunity; however, recent literature suggests that a paradigm shift is in order. Sterols are …
Immunometabolic function of cholesterol in cardiovascular disease and beyond
L Yvan-Charvet, F Bonacina… - Cardiovascular …, 2019 - academic.oup.com
Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …
Perception of self: distinguishing autoimmunity from autoinflammation
TS Van Kempen, MH Wenink, EFA Leijten… - Nature Reviews …, 2015 - nature.com
Rheumatic diseases can be divided in two groups, autoinflammatory and autoimmune
disorders. The clinical presentation of both types of diseases overlap, but the pathological …
disorders. The clinical presentation of both types of diseases overlap, but the pathological …
Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol
A Civra, V Cagno, M Donalisio, F Biasi… - Scientific reports, 2014 - nature.com
Recent studies reported a broad but selective antiviral activity of 25-hydroxycholesterol
(25HC) against enveloped viruses, being apparently inactive against non-enveloped …
(25HC) against enveloped viruses, being apparently inactive against non-enveloped …
[HTML][HTML] 25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes
A Civra, R Francese, P Gamba, G Testa, V Cagno… - Redox biology, 2018 - Elsevier
A novel innate immune strategy, involving specific cholesterol oxidation products as
effectors, has begun to reveal connections between cholesterol metabolism and immune …
effectors, has begun to reveal connections between cholesterol metabolism and immune …
The roles of cholesterol and its metabolites in normal and malignant hematopoiesis
H Oguro - Frontiers in endocrinology, 2019 - frontiersin.org
Hematopoiesis is sustained throughout life by hematopoietic stem cells (HSCs) that are
capable of self-renewal and differentiation into hematopoietic progenitor cells (HPCs). There …
capable of self-renewal and differentiation into hematopoietic progenitor cells (HPCs). There …
G‐protein coupled receptors and ligands that organize humoral immune responses
E Lu, JG Cyster - Immunological reviews, 2019 - Wiley Online Library
B‐cell responses are dynamic processes that depend on multiple types of interactions. Rare
antigen‐specific B cells must encounter antigen and specialized systems are needed …
antigen‐specific B cells must encounter antigen and specialized systems are needed …
Biomembranes in atomistic and coarse-grained simulations
K Pluhackova, RA Böckmann - Journal of physics: condensed …, 2015 - iopscience.iop.org
The architecture of biological membranes is tightly coupled to the localization, organization,
and function of membrane proteins. The organelle-specific distribution of lipids allows for the …
and function of membrane proteins. The organelle-specific distribution of lipids allows for the …