Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal
cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

Steroids are highly prevalent structures in small‐molecule therapeutics, with the level of
oxidation being key to their biological activity and physicochemical properties. These C …

Abstract Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated
metabolite DHEA-S are the most abundant steroids in circulation and decline with age …

3-Methoxy-17α-ethynylestradiol or mestranol is a prodrug for ethynylestradiol and the
estrogen component of some oral contraceptive formulations. We demonstrate here that a …

Dehydroepiandrosterone (DHEA) levels were reported to associate with increased breast
cancer risk in postmenopausal women, but some carcinogen-induced rat mammary tumor …

Little is known about the regulation of the oncomiR miR-21 in liver. Dehydroepiandrosterone
(DHEA) regulates gene expression as a ligand for a G-protein-coupled receptor and as a …

Blood pressure is lower in premenopausal women than in age-matched men; after
menopause blood pressure values and the prevalence of hypertension show opposite …

Scope Several lines of evidence suggest that the consumption of cruciferous vegetables is
beneficial to human health. Yet, underlying mechanisms and key molecular targets that are …